| Club | Sponsor | Info Link | |
| Art Club | Shannon Tucking, Angie Carmack | https://sites.google.com/ksdr1.net/khsdigitalarts/home | |
| Book Club | Sherry Crall | None | |
| Creative Writing Club | Amanda Collier | https://sites.google.com/ksdr1.net/mrs-amanda-collier/home | |
| Boys Volleyball | Kathryn Cash | None | |
| Bridging the Gap | Janelle Veith | None | |
| DECA | Jennifer Remley | http://deca.org/ | |
| Kearney Theatre Club | Haley Kernes | Kearney.Theatre on Instagram | |
| FBLA (Future Business Leaders of America) | Alyssa Stevens | https://www.fbla-pbl.org/ | |
| FCA (Fellowship of Christian Athletes) | Mandy Jury | None | |
| FCCLA (Family, Career, & Community Leaders of America) | Kassidy Robertson and Kathryn Cash | None | |
| FFA (Future Farmers of America) | Erica Hart | https://sites.google.com/students.kearney.k12.mo.us/khsffa/home | |
| Real World Learning | Stacy Holtzclaw and Janelle Veith | None | |
| Sign Language Club | Alyssa Stevens, Stacey Reisig, Brittini Starzl | None | |
| German Club | Stacey Getz | None | |
| Law Sports Club | Angie Carmack and Jennifer Remley | https://sites.google.com/ksdr1.net/khsdigitalarts/home
| |
| HOSA (Health Occupations Students of America) | Kelsey Colwell | None | |
| KHS PTO | Jessica Trammell | None | |
| KHS-TV | Heather Rimmer | None | |
| KIND Club (Kindness, Inclusion, & Diversity) | Jennifer West and Ashlee James | https://sites.google.com/ksdr1.net/khskindclub/home | |
| National Honor Society | | | |
| Robotics | Justin Leon | https://sites.google.com/ksdr1.net/kearneyrobotics-team2345/home
| |
| Ski Club | Shannon Tucking | None | |
| Scholar Bowl | Elizabeth Mael | None | |
| Science Club | Justin Leon | https://sites.google.com/ksdr1.net/leon/science-club | |
| Speech & Debate | Ashley Weaver | None | |
| Sports & Entertainment Arts (SEA) | Angie Carmack | @kmosports on Instagram, Facebook and Twitter | |
| Students Against Destructive Decisions | Mendy Salmonson | www.sadd.org | |
| Student Council | Brittini Starzl | None | |
| Trapshooting | Erica Hart | None | |
